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The report focuses on two major applications of systems-engineering tools: (1) systems design, analysis, and control tools to promote a better understanding of health care processes and interactions and improve system performance within the severe constraints of a crisis situation; and (2) information and communications technologies to facilitate information flow, connectivity at all levels (patients, care teams, health care organizations, and the larger regulatory and financial environment), and coordinated, patient-centered health care. In addition to the committee's consensus report, this volume includes 38 individually authored papers based on presentations given at three fact-finding workshops. The papers address not only operational challenges confronting the U.S. health care delivery system, but also opportunities for improving the use of information technology (e.g., biosensors and wireless communications, and remote monitoring) and systems engineering (e.g., human factors engineering, financial engineering, supply-chain management, and modeling and simulation).