In This Issue
Engineering and Vaccine Production for an Influenza Pandemic
September 1, 2006 Volume 36 Issue 3
Articles In This Issue
  • Friday, September 1, 2006
    AuthorArthur H. Heuer

    Editor’s Note

    Every year, influenza A and B cause epidemics that lead to an average of 36,000 deaths and 114,000 hospitalizations in the United States alone. Periodically, new influenza strains evolve with the capacity to cause pandemics (epidemics that spread around the globe). The ...

  • Friday, September 1, 2006
    AuthorJames T. Matthews

    Despite improvements in technology and increased automation, egg-based vaccine production still has a long timeline.

    The two influenza viruses that are medically and clinically important to the human population, known as Type A and Type B, are segmented, negative-strand genomes with an envelope ...

  • Friday, September 1, 2006
    AuthorAlan Shaw

    The keys to survival of a pandemic will be surveillance, public health planning, and a publicly agreed strategy for behavior.

    When talking about the development of vaccines to avert an influenza pandemic, we must keep in mind a sobering fact. A very well run vaccine development program, from ...

  • Friday, September 1, 2006
    AuthorRino Rappuoli

    The next generation of influenza vaccines will be cell-culture-based for seasonal influenza and for pandemics.

    Leading manufacturers of vaccines and antiviral drugs are working hard to develop new and novel methods of preparing seasonal influenza vaccines, as well as pandemic vaccine candidates. ...

  • Friday, September 1, 2006
    AuthorPatrick J. Scannon

    H5N1 may be the first real test of a rapid pharmaceutical response to a pandemic.

    As H5N1 spreads around the world, the requirements for pandemic preparedness are being discussed on an unprecedented international scale. Despite an increasing awareness of need, the question remains: is the ...

  • Friday, September 1, 2006
    AuthorRoy M. Anderson

    Health care providers and public health officials can use proven mathematical models to plan responses to a pandemic.

    In the past decade, major changes have been made in the way governments and international agencies plan for the management and control of epidemics. These changes have been ...